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File Name: microtek_a3_16132.zip
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The compositions comprise trans- resveratrol, a metal chelator, and one or more additional antioxidants such as phenolic antioxidants or vitamin D. The so-called 'French Paradox' a low mortality rate specifically from cardiovascular diseases may be due mainly to the regular consumption of wine Renaud, Microtek A3-1602 Plus Scanner. In particular, resveratrol is believed to be beneficial to the functioning of the heart and in extending the life of human cells. Resveratrol, when used in dietary supplements, is generally produced as an alcohol extract from plant sources.

Mice have been used extensively as a model for genetic expression comparisons with humans. It would therefore be desirable to provide an alternative route to obtaining the benefits of calorie restriction that would avoid the need for dietary regulation and that would be amenable to widespread adoption. The present embodiments are directed to this and other needs. The frans-resveratrol may be encapsulated to substantially preserve the biological activity of the composition from loss due to exposure of the frans-resveratrol to light or oxygen. Additional embodiments provide a method of protecting Microtek A3-1602 Plus Scanner stem cells by administering a composition that comprises frans-resveratrol, a metal chelating agent, and one or more additional antioxidants such as apigenin, caffeic acid, EGCG, ferulic acid, quercetin, or vitamin D in conjunction with or following stem cell implantation.

These compositions exhibit numerous benefits as compared to pure resveratrol alone.

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Resveratrol [ ] Resveratrol has been ascribed multiple beneficial biological effects see, e. Studies have shown that resveratrol is biologically active, providing several health benefits including cancer prevention, anti-inflammatory properties, and cardiovascular effects. To maintain biological activity for an "extended period" of time, the small molecules of plant or synthetic source preferably remain biologically active for time periods after which the molecules would naturally become biologically Microtek A3-1602 Plus Scanner due to degradation or molecular isomerization as a result of exposure to light, heat or oxygen.


These destructive processes would likely occur during extraction, encapsulation or storage. For example, resveratrol possesses a half- life of approximately one day; consequently, it typically loses significant biological Microtek A3-1602 Plus Scanner within two days of exposure to ambient conditions and during processing of dietary supplements.


Preferably, the resveratrol used in the present compositions is entirely or primarily e. Resveratrol is found in at least 72 species of plants distributed among 31 genera and 1 2 families.

All of the families found to contain resveratrol belong to the spermatophytes division: Resveratrol has most often been reported in non-edible plants: Resveratrol is particularly found in grape skins and Giant Knotweed, cocoa and chocolate. Peanut sprouts are also a rich source of resveratrol.

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Another preferred source is Polygonum Giant Knotweed and, in particular, Polygonum cuspidatum a species of giant knotweed. The natural derivation process includes those processes generally known in the art, including an extraction process in which a solvent is used to extract the small molecules from a Microtek A3-1602 Plus Scanner source. The solvent includes aqueous solvents, organic solvents, and mixtures thereof. The solvent may include, but is not limited to, alcohols such as ethanol.

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By way of specific examples, the extracted material may include aqueous or organic solvent extracts of plants or parts thereoffruit juices e. The extracted material may further include inert plant material naturally removed during the extraction process.

For example, the solvent may be removed from the extract e. In a preferred embodiment, the compositions comprise or consist essentially of a mixture of grape and Polygonum extracts, each comprising trans-resveratrol.

As used herein, the term "extract" or "plant extract" has its ordinary meaning of a concentrated pharmaceutical preparation of a plant obtained by removing active constituents such as trans- resveratrol with a suitable solvent or menstruum, which is evaporated away or otherwise removed to yield a residual mass of plant extract. The extract may be adjusted to a prescribed standard. Thus, it is understood by those skilled in the art that an "extract" or "plant extract" is not simply a pure active ingredient or ingredients, but instead contains secondary material from the source plant, for example, depending on the source Microtek A3-1602 Plus Scanner, organic and inorganic salts, organic bases and acids, saponins, polyphenols, tannins, sugars, polysaccharides, etc.


In another preferred embodiment, trans-resveratrol is present in the composition in an amount of about 12, 3, 4, 5, 6, 7, 8, 9, 10, 1 11 2, 1 3, 14, 1 5, 1 6, 1 7, 18, 1 9, 20, 2122, 23, 24, 25, 26, 27, 28, 29, 30, 3132, 33, 34, 35, 36, 37, 38, 39, 40, 4142, 43, 44, 45, 46, 47, 48, 49, 50, 5152, 53, 54, 55, 56, 57, 58, 59, 60, 6162, 63, 64, 65, 66, 67, 68, 69, 70, 7172, 73, 74, 75, 76, 77, 78, 79, 80, 8182, 83, 84, 85, 86, 87, 88, 89, 90, 91 Microtek A3-1602 Plus Scanner, 92, 93, 94, 95, 96, 97, 98, 99 or mg trans-resveratrol per kilogram of patient, or about 5, 10, 1 5, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, 1 10, 1 1 5, 1 20, 1 25, 1 30, 1 35, 1 40,1 50, 1 55, 1 60, 1 65, 1 70, 1 75, 1 90, 1 95 or mg trans- resveratrol per kilogram of patient. The trans-resveratrol may also be present in any range between any two of these amounts, e. In a preferred embodiment, trans-resveratrol is present in the composition in an amount of about 1.

Chelators [] As used herein the term "chelator" refers to an organic compound that bonds with Microtek A3-1602 Plus Scanner removes free metal ions from solution. Examples of suitable chelators include ethylenediaminetetraacetic acid EDTAhistidine, antibiotic drugs of the tetracycline family, pyridoxal 2-chlorobenzoyl hydrazone, desferrioxamine, dexrazoxane, deferasirox, pyoverdine, pseudan, citrate, NDGA nordihydroguaiaretic acid: Preferably, the compositions of the present embodiments will provide a composition dosage of chelator of from about 1 g to about 1 5 g, more preferably from about 2 g to about 1 2 g. As used herein, the term "phytic acid" refers to inositol hexaphosphate 2,3,4,5,6- pentaphosphonooxycyclohexyl dihydrogen phosphate; also known as "IP6".

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